Great Game

Cosmic Supremacy is a must-try for any 4x addicts in general or MOO/Galactic Civ players specifically.
The game is deep, offering the same sort of strategic options as available in Master of Orion while allowing you to challenge many other players online (I am currently in a galaxy with 42 other players!).
The game maps are also 3D, which is great.
I highly recommend giving this a try.

-Kadath